Dimethyl Sulfoxide (DMSO)

Dimethyl Sulfoxide (DMSO, CAS 67-68-5) is a high-purity polar aprotic solvent manufactured for regulated industrial and pharmaceutical synthesis. Featuring a high dielectric constant and strong solvency for both polar and non-polar compounds, it functions as an essential reaction medium, extractant, and crystallization solvent. Production relies on controlled batch synthesis to maintain low moisture profiles and minimal trace impurities, ensuring predictable performance in multi-step organic synthesis and strict regulatory environments.

 

Product Specifications:

Parameter	Industrial Grade	Pharmaceutical Grade (USP/EP)	Test Method
Assay (Purity)	>= 99.9%	>= 99.9%	GC (Gas Chromatography)
Water Content	<= 0.1%	<= 0.05%	Karl Fischer Titration
Freezing Point	>= 18.4°C	>= 18.4°C	ASTM D1493
Acidity (as CH3SOOH)	<= 0.002%	<= 0.001%	Titrimetry
Residue on Ignition	<= 0.005%	<= 0.002%	Gravimetric Analysis
Density (20°C)	1.100 - 1.104 g/cm3	1.100 - 1.104 g/cm3	Pycnometer

 

Chemical & Physical Properties:

Molecular Formula	C2H6OS
Molecular Weight	78.13 g/mol
CAS Number	67-68-5
Appearance	Clear, colorless, odorless (or faint sulfur odor) liquid
Boiling Point	189°C (372°F) at 760 mmHg
Melting / Freezing Point	18.4°C (65.1°F) - Note: Solidifies at room temperature below 18.4°C; requires controlled warming rooms for handling during winter transport.
Flash Point	87°C (189°F, Closed Cup)
Solubility	Miscible with water, ethanol, acetone, ether, benzene, and chloroform.

 

Applications
Pharmaceutical Synthesis: Acts as an inert reaction solvent for fluorination, cyanation, alkylation, and oxidation reactions (e.g., Swern oxidation), and serves as a medium for active pharmaceutical ingredient (API) crystallization.
Agrochemical Formulation: Utilized as a co-solvent and penetration enhancer in systemic pesticide and herbicide formulations to optimize active ingredient delivery.
Polymer & Fiber Processing: Functions as a spinning solvent for polyacrylonitrile (PAN) and related synthetic fibers, and a reaction medium for specialized engineering resins.
Electronic Materials: Applied in photoresist strippers and surface cleaning formulations for semiconductor and printed circuit board manufacturing due to its strong solvency for organic residues.

 

Pharmaceutical Manufacturing Relevance
Pharmaceutical-grade DMSO is synthesized and handled under strict quality management frameworks aligned with ICH Q7 guidelines for Active Pharmaceutical Ingredients and advanced intermediates.
Impurity Profile: Controlled trace sulfur compounds and heavy metals meet USP and EP monographs, mitigating unwanted side reactions during sensitive API synthesis.
Residual Solvent Status: Classified as a Class 3 residual solvent (low toxic potential) per ICH Q3C guidelines, reducing regulatory friction during finished drug product submissions (DMF / ANDA / NDA).
Audit Readiness: Manufacturing facilities maintain complete audit trails, validated cleaning procedures, and robust change control protocols to support customer quality audits.

 

Grade & Quality Requirements:
Industrial Grade (99.9%): Optimized for polymer processing, chemical synthesis, and industrial cleaning where moisture and trace heavy metals must remain below strict operational thresholds.
Pharmaceutical Grade (USP / Ph. Eur.): Manufactured for use in drug substance synthesis, complying fully with United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) monographs. Each batch undergoes rigorous testing for related organic impurities and water content.

 

Quality Control:
Batch release requires passing multi-stage analytical testing before shipment.
Testing Instruments: Agilent Gas Chromatographs (GC) equipped with FID detectors for assay and residual volatile impurities; Metrohm Karl Fischer titrators for precise moisture quantification.
Traceability: Every container is labeled with a unique batch number mapped directly to raw material lot records, production operator logs, and master instrument calibration logs.
Retention Samples: Representative reserve samples from every production batch are retained for a minimum of 3 years to ensure retrospective verification capability.

 

Technical Documents：
COA (Certificate of Analysis): Specific batch test results, including exact assay percentage, moisture value, and physical constants, supplied with every shipment.
SDS (Safety Data Sheet): Comprehensive hazard identification, GHS classification, personal protective equipment (PPE) requirements, and spill response procedures compliant with OSHA and REACH standards.TDS (Technical Data Sheet): Summary of physical characteristics, recommended handling parameters, and packaging options.

 

Packaging & Storage:
Packaging Options:
Carbon steel or stainless-steel ISO tanks (approx. 22 - 24 MT)
Internally lined heavy-duty steel drums (225 kg net weight)
Intermediate Bulk Containers (IBC / Tote tanks, 1000 kg net weight)
Storage Conditions: Store in tightly sealed containers in a dry, well-ventilated area away from strong oxidizing or reducing agents.
Temperature Control: Because DMSO freezes at 18.4°C, storage and warehouse facilities must maintain temperatures above 20°C to prevent crystallization. If frozen, containers should be warmed gently in a dedicated warm room (not exceeding 40°C) and thoroughly homogenized prior to use.

 

Supply & Procurement：
Minimum Order Quantity (MOQ): 1 drum (225 kg) for evaluation; 1 FCL (20 MT) or ISO tank for commercial contract pricing.
Sample Policy: 500 mL analytical samples available for qualified industrial and pharmaceutical laboratories. Freight charges apply.
Lead Time:
Spot orders: 7 - 10 business days from order confirmation for standard drum stock.
Bulk ISO tanks / Scheduled blanket orders: Coordinated via customized supply chain logistics schedules.
Bulk Supply Stability: Backed by dedicated annual production capacity and multi-plant regional warehousing to prevent supply chain disruption.

 

OEM / Custom Specification：
Custom packaging solutions, private-label drum stenciling, and specialized container purging (e.g., nitrogen blanket sealing) can be arranged for bulk contract buyers.
Tailored specifications regarding maximum permissible water limits or specific trace impurity controls are evaluated via technical review with our process engineering team.

 

 

Request a Quote：
Submit your required volume, destination port, target delivery schedule, and grade specification (Industrial or USP/EP) to receive a commercial quotation and current batch COA within 24 business hours.

 

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