1,3-Dimethyl-2-imidazolidinone

1,3-Dimethyl-2-imidazolidinone (DMI) | Bulk & Pharmaceutical Grade:

1,3-Dimethyl-2-imidazolidinone (DMI) functions as a high-purity polar aprotic solvent. Driven by its five-membered cyclic urea structure and strong hydrogen-bond acceptance capability, it accelerates nucleophilic substitution reactions, lowers reaction activation energy, and remains stable in strong alkaline and acidic environments. Manufacturing facilities deploy DMI as a reaction medium and extraction solvent where conventional solvents like DMF, DMSO, or HMPA fail to deliver sufficient chemical resistance or targeted yield rates.

 

Product Specifications:

CAS Number	80-73-9
Molecular Formula	C5H10N2O
Molecular Weight	114.15 g/mol
Assay (GC)	>= 99.5% (Pharmaceutical Grade), >= 99.0% (Industrial Grade)
Water Content (Karl Fischer)	<= 0.05%
Free Amine (as Methylamine)	<= 0.01%
Color (APHA)	<= 10

 

Chemical & Physical Properties:

Appearance	Clear, colorless liquid
Density (25 C)	1.056 g/cm3
Boiling Point	225 C at 760 mmHg
Melting Point	8.2 C
Flash Point (Closed Cup)	107 C
Refractive Index (nD20)	1.471 - 1.473
Solubility	Miscible with water, alcohols, ethers, esters, ketones, and aromatic hydrocarbons.

 

Applications:

Organic Synthesis: Operates as a reaction medium for alkylation, condensation, fluorination, and substitution processes. Solvates cations efficiently to increase reaction kinetics.

Polymer Production: Functions as a polymerization solvent for aramides, polyimides, and polyphenylene sulfide, securing high molecular weight distributions and clear polymer solutions.

Electronics & Energy: Utilized in photoresist stripping formulations and as a co-solvent in lithium-ion battery electrolyte systems based on its wide electrochemical stability window.

Surface Treatment: Acts as a modifier and cross-linking agent for synthetic resins and performance coatings.

 

Pharmaceutical Manufacturing Relevance:

Pharmaceutical synthesis applications demand strict solvent purity to prevent side reactions during API production. DMI serves as a reaction solvent for peptide synthesis, heterocyclic ring formation, and substitution workflows involving fluorinated intermediates. Its solubilizing capacity for polar organic and inorganic salts enables reactions to proceed at reduced temperatures and shorter cycle times. Trace impurity profiles below 0.05% moisture minimize hydrolysis risks in moisture-sensitive intermediates.

 

Grade & Quality Requirements:

Pharmaceutical Grade (Ph.G.): Purity >= 99.5%, moisture <= 0.03%, heavy metal residues <= 1 ppm, specified for API and intermediate synthesis.
Industrial Grade (Ind.G.): Purity >= 99.0%, moisture <= 0.05%, specified for polymer manufacturing, resin modification, and specialty cleaning formulations.

 

Quality Control:

Production batches undergo verification via Gas Chromatography (GC) using an FID detector to quantify assay percentages and identify organic impurities. Moisture is measured via Karl Fischer titration under a dry nitrogen purge to eliminate atmospheric interference. Analytical instrumentation is calibrated against NIST-traceable standards. Retained samples from every production lot are archived for 24 months to maintain complete batch traceability.

 

Technical Documents:

COA (Certificate of Analysis): Lot-specific analytical data sheet covering exact GC assay, moisture content, density, and color value supplied with every shipment.

SDS (Safety Data Sheet): Safety documentation detailing GHS classification, handling precautions, toxicological data, and spill response procedures compliant with OSHA and EU REACH regulations.

TDS (Technical Data Sheet): Standardized parameter breakdown, recommended storage conditions, and handling directives.

 

Packaging & Storage:

Standard Packaging:
200 kg net carbon steel drums with inner fluoropolymer coating.
1,000 kg Intermediate Bulk Containers (IBC) / Tote tanks.
ISO tanks for bulk liquid transport.
Storage Conditions: Store in sealed containers under a dry nitrogen blanket. Maintain in a cool, dry, well-ventilated area isolated from strong oxidizing agents and moisture sources. DMI is hygroscopic; prolonged exposure to ambient air degrades purity via moisture absorption.
Shelf Life: 24 months from the manufacturing date when maintained in original unopened containers.

 

Supply & Procurement:

MOQ (Minimum Order Quantity): 1 drum (200 kg) for spot orders; customized volumes arranged for long-term supply agreements.

Sample Policy: 500 mL laboratory test samples supplied for qualified industrial buyers and testing laboratories. Freight charges apply.

Lead Time:

lSpot orders: 7 to 10 business days from order confirmation.

lBulk ISO tank orders: 15 to 25 business days.

Bulk Supply: Annual supply agreements (LSAs) supported by dedicated reactor capacity and scheduled monthly deliveries.

 

OEM / Custom Specification:

Custom purification runs and specialized packaging configurations are available for industrial clients requiring adjusted moisture thresholds, custom drum labeling, or unique container volumes. Batch-specific analytical testing profiles can be aligned with internal client QC standards.

 

 

Request a Quote:
Submit volume requirements, delivery destination, and required grade specifications to receive a commercial proposal.

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