Polyethylene Glycol 600 (PEG 600)

Polyethylene Glycol 600 (PEG 600)：

Polyethylene Glycol 600 (CAS No. 25322-68-3) is a low molecular weight condensation polymer of ethylene oxide and water, characterized by an average molecular weight range of 570 to 630 g/mol. It functions as a non-volatile, hydrophilic, and chemically stable medium utilized in pharmaceutical compounding, personal care formulations, and industrial processing fluids. At ambient temperature, it exists as a clear, viscous liquid completely miscible with water and polar organic solvents. Manufactured for continuous compounding and chemical synthesis, this grade provides consistent hydroxyl functionality and low volatile organic impurity profiles to prevent batch discrepancies in industrial lines.

 

Product Specifications：

Grade Availability	USP-NF / EP Compliant / Industrial Technical Grade
Average Molecular Weight	570 - 630 g/mol
Hydroxyl Value	178 - 197 mg KOH/g
Water Content (Karl Fischer)	<= 0.5%
pH Value (5% aqueous solution at 25°C)	5.0 - 7.0
Dynamic Viscosity (25°C)	105 - 130 mPa*s
Sulfated Ash	<= 0.1%
1,4-Dioxane	<= 10 ppm
Ethylene Oxide	<= 1 ppm
Heavy Metals (as Pb)	<= 5 ppm

 

Chemical & Physical Properties ：

Molecular Formula	H(OCH2CH2)nOH (n approx. 12-13)
Appearance	Clear, colorless to pale yellow viscous liquid
Density (20°C)	1.12 - 1.13 g/cm3
Flash Point (Cleveland Open Cup)	> 200°C
Boiling Point	> 250°C (thermal decomposition occurs prior to boiling)
Hygroscopicity	High; absorbs atmospheric moisture rapidly due to terminal hydroxyl groups and ether linkages.
Thermal Stability	Stable up to 150°C in closed systems; auto-oxidation accelerates above 50°C in the presence of air unless blanketed with inert gas.

 

Applications:

Pharmaceutical Manufacturing: Functions as a solvent, humectant, and vehicle for liquid and semi-solid oral syrups, topical ointments, and suppository bases; acts as a co-solvent to enhance the solubility of poorly water-soluble active pharmaceutical ingredients (APIs).

Personal Care & Cosmetics: Utilized as a humectant, binder, and viscosity-controlling agent in oral hygiene products, skin lotions, and surfactant-based formulations.

Textile Processing: Operates as a lubricating agent, softener, and antistatic additive in synthetic fiber spinning finishes and yarn sizing baths.

Metalworking & Lubricants: Serves as a water-soluble base fluid and friction modifier in synthetic metal cutting fluids, hydraulic fluids, and wire-drawing compounds.

Plastics & Polyurethanes: Functions as an internal mold release agent, plasticizer, and pigment dispersant in polymer compounding.

 

Pharmaceutical Manufacturing Relevance:

Meets strict regulatory impurity thresholds required for secondary pharmaceutical excipients. The verified low concentration of residual ethylene oxide (< 1 ppm) and 1,4-dioxane (< 10 ppm) minimizes cytotoxic risks in topical and oral delivery systems. The tightly controlled hydroxyl value ensures stoichiometric predictability when reacting with fatty acids to synthesize non-ionic surfactants (PEG esters) and emulsifiers.

 

Grade & Quality Requirements:

USP-NF Grade: Certified for compliance with United States Pharmacopeia monographs, intended for pharmaceutical formulation and excipient usage.

EP Grade: Complies with European Pharmacopoeia standards, suitable for distribution within EU regulatory frameworks.

Industrial Grade: Tailored for chemical synthesis, textiles, and technical lubricants where strict pharmacopeial limits are unnecessary, reducing raw material procurement costs without compromising functional viscosity parameters.

 

Quality Control:

Testing Protocol: Every production lot undergoes mandatory pre-shipment testing via automated Karl Fischer titration for moisture, falling-ball or rotational viscometry for dynamic viscosity at 25°C, and chemical titration for hydroxyl value determination.

Traceability: Retained reference samples from each production batch are archived for 24 months in temperature-controlled facilities to support root-cause analysis and regulatory audit verification.

Analytical Instrumentation: Gas chromatography (GC) is deployed for residual monomer quantification (ethylene oxide and 1,4-dioxane), and atomic absorption spectroscopy is used for heavy metal verification.

 

Technical Documents:

COA: Lot-specific Certificate of Analysis available for immediate download or dispatch upon shipment. Includes actual measured values for molecular weight, viscosity, water content, and pH.

SDS: Safety Data Sheet compliant with GHS and OSHA/REACH standards, outlining handling precautions, personal protective equipment (PPE), and emergency spill response protocols.

TDS: Technical Data Sheet detailing physical constants, recommended processing windows, and storage guidelines.

 

Packaging & Storage:

Packaging Options:

l200 kg new galvanized steel or polyethylene drums

l1,000 kg IBC totes (Intermediate Bulk Containers) with tamper-evident seals

lISO tank containers for dedicated bulk liquid deliveries

Storage Conditions: Store in tightly sealed containers in a cool, dry, well-ventilated facility away from strong oxidizing agents such as concentrated nitric acid, perchlorates, or peroxides.

Shelf Life: 24 months from the date of manufacture when stored in original unopened containers under recommended warehouse conditions (15°C - 30°C).

 

Supply & Procurement:

MOQ: 1 drum (200 kg) for standard spot orders; 1 metric ton for customized delivery schedules.

Sample: 500 g laboratory evaluation samples available upon request for incoming quality control (IQC) testing and formulation trials.

Lead Time: 7 to 14 business days for regional warehouse inventory; 30 to 45 days for factory-direct full-container load (FCL) maritime shipments.

Bulk Supply: Annual supply contracts (volume commitments with scheduled quarterly or monthly call-offs) supported to hedge against chemical raw material price volatility.

 

OEM / Custom Specification:

Custom Molecular Weight Distribution: Narrowed molecular weight ranges available upon request for specific synthesis requirements.
Packaging Customization: Private labeling, customized drum stenciling, or customer-specified lot numbering formats available for bulk containerized orders.
Additive Adjustments: Supply without antioxidants or with customized preservative packages upon formal technical review and stability testing.

 

 

Request a Quote:
Provide chemical grade requirements, annual consumption volume, delivery port, and packaging preference to receive a commercial quotation including freight terms and current lot COA data.

 

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