N-Isopropylhydroxylamine

N-Isopropylhydroxylamine (CAS 5080-22-8) | Industrial-Grade Manufacturer & Bulk Supply Portal:

N-Isopropylhydroxylamine (NIPHA / IUPHA, CAS No. 5080-22-8) is an organic hydroxylamine derivative functioning as a high-efficiency free-radical scavenger, polymerization inhibitor, and specialized reducing intermediate. Structurally bridging the gap between hydroxylamine and secondary amines, it delivers precise reaction control in emulsion polymer manufacturing and acts as an alternative volatile oxygen scavenger in high-pressure industrial boiler water systems. Available in stable crystalline solid and controlled aqueous solution forms, it integrates directly into continuous industrial chemical processes requiring stringent redox management.

 

Product Specifications:

Chemical Name	N-Isopropylhydroxylamine
CAS Registry Number	5080-22-8
Molecular Formula	C3H9NO
Molecular Weight	75.11 g/mol
Structural Formula	(CH3)2CHNHOH
Appearance	White to off-white crystalline flakes (Solid grade) or colorless to pale yellow liquid (Aqueous grade)
Standard Assay (Purity)	>= 98.0% (HPLC / Titrimetric)
Water Content (Moisture)	<= 0.5% (Solid grade)

 

Chemical & Physical Properties:

Melting Point: 45°C - 50°C (Pure substance)

Boiling Point: Approx. 110°C at 760 mmHg (undergoes thermal decomposition under prolonged high-heat exposure)

Density: 0.92 g/cm3 at 20°C (85% aqueous solution)

pH Value: 9.0 - 11.0 (1% aqueous solution at 25°C)

Solubility: Fully miscible with water, lower alcohols, and polar organic solvents.

Thermal Stability: Stable under ambient storage conditions; exothermic decomposition initiates above 120°C. Segregate strictly from strong oxidizing agents, mineral acids, and active catalysts.

 

Applications:

Polymerization Short-Stop Agent: Deployed in emulsion polymerization lines for styrene-butadiene rubber (SBR) and nitrile-butadiene rubber (NBR). It terminates free-radical chain propagation at exact conversion thresholds, arresting gelation and preventing polymer degradation.
Boiler Feedwater Oxygen Scavenger: Functions as a volatile, non-amine-based oxygen scavenger in high-pressure steam utility systems. It reacts with dissolved oxygen without depositing metallic residues or elevating total dissolved solids (TDS), replacing traditional hydrazine or hydroquinone formulations.
Fine Chemical Synthesis: Serves as an alkylhydroxylamine intermediate in agrochemical and specialty chemical pathways requiring selective N-O bond construction.

 

Pharmaceutical Manufacturing Relevance:

Utilized as a specialized reactant and reductive intermediate within upstream active pharmaceutical ingredient (API) synthesis pathways.

Impurity Profile Control: Manufactured via optimized synthetic routes keeping trace heavy metals below 10 ppm and limiting residual organic solvents, meeting ICH Q3D elemental impurity specifications.

Batch Traceability: Production runs adhere to strict validation parameters, delivering the analytical transparency required for drug master file (DMF) compilation and regulatory audits.

 

Grade & Quality Requirements:

Industrial Grade (Solid / 98%): Optimized for synthetic rubber and bulk polymer manufacturing. Features low insoluble residue limits to prevent fouling in continuous feed injection lines.

Water Treatment Grade (Aqueous / 85%): Filtered to 0.5-micron thresholds to ensure particle-free metering in automated boiler water treatment skids.

Synthesis Grade (High-Purity / 99%): Designed for sensitive organic synthesis requiring strict caps on chloride and sulfate ionic contaminants.

 

Quality Control:

Manufacturing processes operate under ISO 9001:2015 certified quality management systems.

Testing Methods: Assayed via high-performance liquid chromatography (HPLC) and non-aqueous titration. Moisture content quantified through Karl Fischer titration.

Batch Verification: Retained reference samples from every commercial production lot are archived for 24 months under climate-controlled conditions. Pre-shipment Certificates of Analysis (COA) reflect actual laboratory test results of the dispatched batch.

 

Packaging & Storage:

Solid Grade Packaging: 25 kg fiber drums with inner polyethylene liners, or 500 kg / 1000 kg FIBC bulk bags equipped with moisture-barrier liners.

Liquid Grade Packaging: 200 L high-density polyethylene (HDPE) drums (net weight 200 kg) or 1000 L IBC intermediate bulk containers.

Storage Conditions: Store in a cool, dry, well-ventilated location away from direct sunlight and external heat sources. Maintain storage temperatures below 30°C. Keep containers tightly sealed to mitigate moisture absorption and atmospheric oxidation. Shelf life: 12 months from manufacture date under designated storage parameters.

 

Supply & Procurement:

MOQ (Minimum Order Quantity): 100 kg for laboratory evaluation orders; 1 metric ton (MT) for standard commercial sea freight consignments.

Sample Policy: 100g to 500g analytical samples provided for laboratory qualification. Freight collect via DHL/FedEx, or shipping expenses credited toward the initial commercial purchase order.

Lead Time:

Ex-stock standard grades: 7 to 10 business days for container dispatch.

Custom bulk production: 15 to 25 business days from contract execution.

Bulk Supply Capabilities: Annual supply agreements (volume commitments paired with scheduled quarterly call-offs) supported by dedicated manufacturing capacity. Export packaging fully complies with IMDG and ADR marine and land transport regulations.

 

OEM / Custom Specification:

Custom formulations and packaging adjustments are engineered for industrial partners facing specific plant engineering constraints.

Concentration Tuning: Aqueous solutions formulated between 80% and 90% active content to match precise client dosing pump specifications.

Custom Packaging: Private labeling, client-designated drum stenciling, and specialized palletization (heat-treated wooden pallets compliant with ISPM 15) available for long-term supply contracts.

 

 

Request a Quote:
Submit your technical specifications, required volume, and delivery destination to receive a commercial quotation including FOB/CIF pricing and the current batch COA.

 

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